金俊飞
职  称: 研究员
职  务: 副院长、中心实验室主任、肝胆胰外科实验室主任、临床医学研究中心主任等
学  历: 博士研究生
所在科室: 中心实验室、肝胆胰外科实验室
出诊时间:

金俊飞,桂林医学院附属医院副院长,桂林医学院研究员,曾任美国南卡罗莱纳医科大学Assistant Professor(Visiting,Faculty),东南大学遗传学博士,留美国博士后。在美国工作近10年后被桂林医学院以高层次人才引进。是广西优秀专家,广西高校引进海外高层次人才“百人计划”入选者(第一批,2013),桂林市拔尖人才(第四批,2014),桂林市漓江学者(第二批,2016),中南大学湘雅医院博士生导师。是桂林医学院“神经鞘脂与相关疾病”创新团队负责人,组建了 “中美健康与疾病脂质研究中心”,是桂林医学院肿瘤学学科带头人。

目前是桂林医学院学术委员会副主任,桂林医学院广西肝脏损伤与修复分子医学重点实验室”执行主任,桂林医学院临床医学研究中心主任,桂林医学院“中美健康与疾病脂质研究中心” 主任,桂林医学院附属医院中心实验室主任、桂林医学院附属医院肝胆胰外科实验室主任。

在神经鞘脂信号通路、凋亡信号通路、TLR4信号通路与细胞行为及相关疾病中的作用研究中取得了多项原创性成果,到目前为止共发表英文文章51篇,其中SCI文章49篇,在49SCI的文章中第一作者(包括并列第一作者)和通讯作者占33篇;很多文章发表在国际知名杂志,比如Nat Rev Immunol. (影响因子39.932),Nat Rev Clin Oncol.(影响因子20.693),Oncoimmunology(影响因子7.644). FASEB JJ Biol Chem. J. Lipid Res. Biochim Biophys Acta.等,总影响因子约270,文章被引用近800余次(最高单篇被引次数101)。目前主持国家自然科学基金2项 (面上项目及地区项目各一项),广西自然科学基金重大项目1项。是1家英文期刊的主编,是3家英文期刊的编委, 为多家英文期刊审阅过文章。获得广西科学技术进步奖一等奖肝脏损伤与修复的基础与临床应用研究”(排第五,2016)1项,获得桂林市科学技术进步奖一等奖肝脏损伤与修复的基础与临床应用研究”(排第二,2016)1项。

学术成就

(一)英文文章:

1Minglin Lin, Junfei Jin. Cancer, obesity, and diabetes: TKIs exert multiple effects on glucose homeostasis. Nat Rev Clin Oncol. 2017 May;14(5):268. (通讯作者) (2017影响因子20.7)

2Junfei Jin, Songqing He. The complement system is also important in immunogenic cell death. Nat Rev Immunol. 2017 Feb;17(2):143. (通讯作者) (2017影响因子39.9)

3Qun Zhu, Rongping Zhu, Junfei Jin. Neutral ceramidase-enriched exosomes prevent palmitic acid-induced insulin resistance in H4IIEC3 hepatocytes. Published in progress. FEBS Open Bio (2016). (通讯作者) (2016影响因子2.101)

4:Zhu Q, Yang J, Zhu R, Jiang X, Li W, He S, Jin J. Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis. Apoptosis. 2016 Jun 30. (通讯作者) (2016影响因子3.592)

5Huang C, Verhulst S, Shen Y, Bu Y, Cao Y, He Y, Wang Y, Huang D, Cai C, Rao K, Liao DF, Jin J*, Cao D. AKR1B10 promotes breast cancer metastasis through integrin α5/δ-catenin mediated FAK/Src/Rac1 signaling pathway. Oncotarget. 2016 May 27. doi: 10.18632/oncotarget.9672. [Epub ahead of print] (*通讯作者) (2016影响因子5.008)

6:Jessica Heinrichs, Jun Li, Hung Nguyen, Yongxia Wu, David Bastian, Anusara Daethanasanmak, M-Hanief Sofi, Steven Schutt, Chen Liu, Junfei Jin*, Brian Betts, Claudio Anasetti, Xue-Zhong Yu. CD8 Tregs Promote GVHD Prevention and Overcome the Impaired GVL Effect Mediated by CD4 Tregs in Mice. OncoImmunology. (*通讯作者) (2016影响因子7.64)

7Yu-Lan Li, Ming-Lin Lin, Song-Qing He, Jun-Fei Jin*. Sphingolipid metabolism affects the anticancer effect of cisplatin (Review). World J Transl Med. Apr 12, 2016; 5(1): 37-45. (通讯作者) (非SCI)

8Liao W, Wang Y, Liao Y, He S*, Jin J*. Preoperative Aspartate Aminotransferase to White Blood Cell Count Ratio Predicting Postoperative Outcomes of Hepatocellular Carcinoma. Medicine (Baltimore). 2016 Apr; 95(14):e3345. (通讯作者) (2015影响因子5.723) PMID: 27057915

9Jin J*, Liao W, Yao W, Zhu R, Li Y, He S*. Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. Sci Rep. 2016 Mar 7; 6:22746. doi: 10.1038/srep22746. (第一作者,通讯作者) (2015影响因子5.578) PMID: 26948042

10Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ. T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. J Immunol. 2016 Apr 1; 196(7):3168-79. doi: 10.4049/jimmunol.1501020. PMID: 26903480(第作者)(2015影响因子4.922)

11Hedgpeth DC, Zhang X, Jin J, Leite RS, Krayer JW, Huang Y. Periodontal CD14 mRNA expression is downregulated in patients with chronic periodontitis and type 2 diabetes. BMC Oral Health. 2015 Nov 18;15(1):145. doi: 10.1186/s12903-015-0118-3. (第三作者)(2015影响因子1.128)

12Pengpeng Zhu*, Junfei Jin*, Yan Liao, Jun Li, Xue-Zhong Yu, Weijia Liao, Songqing He. A Novel Prognostic Biomarker SPC24 Up-Regulated in Hepatocellular Carcinoma. Oncotarget. 2015 Dec 1;6(38):41383-97. (*并列第一作者)(2015影响因子6.359)

13Cheng Qi, He Song-Qing, Gao Dan, Lei Biao, Long Xin, Liang Hui-Fang, Zhu Peng, Jin Jun-Fei, Tang Bo, Tomlinson Stephen, Wu Zhi-Ying, Chen Xiao-Ping. Early Application of Auxiliary Partial Orthotopic Liver Transplantation in Murine Model of Wilson Disease. Transplantation. 2015 Nov; 99(11):2317-24. (第八作者)(2015影响因子3.828)

14Xiaohu He, Weijia Liao, Yulan Li, Yongqin Wang, Qian Chen, Junfei Jin*, Songqing He* . Upregulation of hyaluronan-mediated motility receptor in hepatocellular carcinoma predicts poor survival, Oncol Lett. 2015 Dec; 10(6):3639-3646. (通讯作者) (2015影响因子1.554)

15Yongxia Wu, Jessica Heinrichs, David Bastian, Jianing Fu, Hung Nguyen, Steven Schutt, Yuejun Liu, Junfei Jin, Chen Liu, Qi-Jing Li, Changqing, Xue-Zhong Yu. MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. Blood. 2015, 126(11):1314-1323. doi: 10.1182/blood-2015-02-627356. Epub 2015 Jul 2. (第八作者)(2015影响因子10.452)

16:Junfei Jin, Pengpeng Zhu, Yan Liao, Jun Li, Weijia Liao, Songqing He. Elevated preoperative aspartate aminotransferase to lymphocyte ratio index as an independent prognostic factor for patients with hepatocellular carcinoma after hepatic resection. Oncotarget. 2015 Aug 7;6(22):19217-27.(第一作者)(2015影响因子6.359)

17Bo Tang, Fang Tang, Bo Li, Shengguang Yuan, Qing Xu, Stephen Tomlinson, Junfei Jin, Wei Hu, Songqing He. High USP22 expression indicates poor prognosis in hepatocellular carcinoma. Oncotarget. 2015 May 20; 6(14):12654-67.(通讯作者)(2015影响因子6.359)

18Li J, Lei B, Nie X, Lin L, Tahir SA, Shi W, Jin J, He S. A comprehensive method for predicting fatal liver failure of patients with liver cancer resection. Medicine (Baltimore). 2015 May; 94(17):e784. doi: 10.1097/MD.0000000000000784. Erratum in: Medicine (Baltimore). 2015 Jun; 94(22):1   (第七作者) (2015影响因子5.723)

19: CHANGMING WANG, XIUPING XUAN, WENMIN YAO, GUOJIN HUANG, JUNFEI JIN. Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats. Molecular medicine reports, 2015, 12(1): 1291-1297. (通讯作者)(2015影响因子1.554)

20:  Zhongyang Lu , Yanchun Li , Junfei Jin , Xiaoming Zhang , Yusuf A. Hannun ,Yan Huang. GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. Atherosclerosis, 2015, 240: 163-173. (第三作者) (2015影响因子3.994)

21:ZHAOQUAN HUANG, GUOJIN HUANG, QUANZHONG LI, JUNFEI JIN. p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation. Biomedical Reports, 2015, 3(2): 225-229.(通讯作者)

22:  Weijia Liao, Guojin Huang, Yan Liao, Jianjun Yang, Qian Chen, ShengJun Xiao, Junfei Jin, Songqing He, Changming Wang. High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma. Oncotarget. 2014 Nov 15;5(21): 10271- 10279.(通讯作者)(2014影响因子6.627)

23:  Qun Zhu, Jian Kang, Heng Miao, Yamin Feng, Lijun Xiao, Zhigao Hu, Duan-Fang Liao, Yan Huang, Junfei Jin, Songqing He. Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect. FEBS J. 2014 Jun; 281(12):2861-2870.(通讯作者)(2014影响因子4.0)

24:  Weijia Liao, Jingmei Zhang, Qun Zhu, Liling Qin, Wenmin Yao, Biao Lei, Wuxiang Shi, Shengguang Yuan, Syed Abdul Tahir, Junfei Jin, Songqing He. Preoperative Neutrophil-to-Lymphocyte Ratio as a New Prognostic Marker in Hepatocellular Carcinoma after Curative Resection. Translational Oncology. 2014 Apr;7(2):248-255.(通讯作者)(2014 影响因子2.6)

25:  Junfei Jin, Erika R. Machado, Hong Yu, Xiaoming Zhang, Zhongyang Lu, Yanchun Li, Maria F.Lopes-Virella, Keith L. Kirkwood, Yan Huang. Simvastatin Inhibits LPS-Induced Alveolar Bone Lossduring Metabolic Syndrome. J Dent Res. 93:294-299, 2014. (第一作者)(2014影响因子4.1)

26:  Junfei Jin, Xiaoming Zhang, Zhongyang Lu, Yanchun Li, Lopes-Virella MF, Yu H, Haycraft CJ, Li Q, Kirkwood KL, Yan Huang. Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease. J Periodontal Res. 2014 Aug; 49(4):518-526. (第一作者)(2014 影响因子2.2)

27:  Wei Zhang, Bao-an Chen, Junfei Jin, You-ji He, Yi-qi Niu. Involvement of c-Jun N-terminal kinase in reversal of multidrug resistance of human leukemia cells in hypoxia by 5-bromotetrandrine. Leuk Lymphoma. 2013 Nov; 54(11):2506-2516. (第三作者)(2013 影响因子2.6)

28:  Zhongyang Lu, Yanchun Li, Devadoss J. Samuvel, Junfei Jin, Xiaoming Zhang, Maria F. Lopes-Virella, Yan Huang. MD-2 Is Involved in the Stimulation of MMP-1 Expression by IFNγ and High Glucose in Mononuclear Cells-A Potential Role of MD-2 in TLR4-Independent Signaling. Immunology. 2013 Nov;140(3):301-313. (第四作者)(2013影响因子3.7)

29:  Junfei Jin, Xiaoming Zhang, Zhongyang Lu, David M. Perry, Yanchun Li, Sarah Brice Russo, L.Ashley Cowart, Yusuf A. Hannun, Yan Huang. Acid Sphingomyelinase Plays a Key Role in Palmitic Acid-Amplified Inflammatory Signaling Triggered by Lipopolysaccharide at Low Concentration in Macrophages. Am J Physiol Endocrinol Metab. 2013 Oct; 305(7):E853-E867. (第一作者)(2013 影响因子4.1)

30:  Q. Zhu, J. J. Zhong, J. F. Jin, X. M. Yin, H. Miao. Tauroursodeoxycholate, a Chemical Chaperone, Prevents Palmitate-induced Apoptosis in Pancreatic β-cells by Reducing ER Stress. Exp Clin Endocrinol Diabetes. 2013 Jan; 121(1):43-47. (第三作者)(2013 影响因子1.8)

31:  Zhongyang Lu, Xiaoming Zhang, Yanchun Li, Junfei Jin, Yan Huang. TLR4 Antagonist Reduces Early-Stage Atherosclerosis in Diabetic Apolipoprotein E-deficient Mice. J Endocrinol. 2013 Jan 2; 216(1):61-71. (第四作者)(2013 影响因子3.6)

32:  Qun Zhu, Lianku Lin, Qi Cheng, Qing Xu, Jingmei Zhang, Stephen Tomlinson, Junfei Jin, Xiaoping Chen, Songqing He. The role of acid sphingomyelinase and caspase 5 in hypoxia-induced HuR cleavage and subsequent apoptosis in hepatocytes. Biochim Biophys Acta. 2012 Dec; 1821(12):1453-1461.(通讯作者)(2012 影响因子4.1)

33:  Zhongyang Lu, Yanchun Li, Junfei Jin, Xiaoming Zhang, Maria F. Lopes-Virella, Yan Huang. Toll-Like Receptor 4 Activation in Microvascular Endothelial Cells Triggers a Robust Inflammatory Response and Cross Talk With Mononuclear Cells via Interleukin-6. Arterioscler Thromb Vasc Biol. 2012, 32:1696-1706. (第三作者)(2012 影响因子6.4)

34:  Junfei Jin, Kamala P. Sundararaj, Devadoss J. Samuvel, Xiaoming Zhang, Yanchun Li, Zhongyang Lu, Maria F. Lopes-Virella, Yan Huang. Different signaling mechanisms regulating IL-6 expression by LPS between gingival fibroblasts and mononuclear cells: seeking the common target. Clin Immunol. 2012 May; 143(2):188-199. (第一作者)(2012 影响因子3.8)

35:  Junfei Jin, Devadoss J. Samuvel, Xiaoming Zhang, Yanchun Li, Zhongyang Lu, Maria F. Lopes-Virella, Yan Huang. Coactivation of TLR4 and TLR2/6 Coordinates an additive Augmentation on IL-6 Gene Transcription via p38 MAPK Pathway in U937 Mononuclear Cells. Mol Immunol. 2011 Dec; 49(3):423-432. (第一作者)(2011 影响因子2.9)

36:  Devadoss J. Samuvel, Junfei Jin, Kamala P. Sundararaj, Yanchun Li, Xiaoming Zhang, Maria F.Lopes-Virella, Yan Huang. TLR4 Activation and IL-6-Mediated Cross Talk between Adipocytes and Mononuclear Cells Synergistically Stimulate MMP-1 Expression. Endocrinology. 2011 Dec;152(12):4662-4671. (第二作者)(2011 影响因子4.5)

37:  Sudha Talwar, Junfei Jin, Brittany Carroll, Angen Liu, Marion Boyd Gillespie, Viswanathan Palanisamy. Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc expression after hypoxic stress. J Biol Chem. 2011 Sep 16; 286(37):32333-32343. (并列第一作者)(2011 影响因子4.8)

38:  Qi Hou, Junfei Jin, Hui Zhou, Sergei A. Novgorodov, Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Yi-Te Hsu. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res. 2011 Feb; 52(2):278-288. (并列第一作者)(2011 影响因子5.6)

39:  Qun Zhu, Bo Shen, Boshao Zhang, Wei Zhang, Steve H. Chin, Junfei Jin, Duan-fang Liao. Inhibition of AMP-activated protein kinase pathway sensitizes human leukemia K562 cells to nontoxic concentration of doxorubicin. Mol Cell Biochem. 2010 Jul; 340(1-2):275-281.(通讯作者)(2010 影响因子2.2)

40:  Ruijuan Xu, Wei Sun, Junfei Jin, Lina M. Obeid, Cungui Mao. Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes. FASEB J. 2010 Jul; 24(7):2507-2515. (第三作者)(2010 影响因子6.5)

41:  Wei Sun, Junfei Jin, Ruijuan Xu, Wei Hu, Zdzislaw M. Szulc, Jacek Bielawski, Lina M. Obeid, Cungui Mao. Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2). J Biol Chem. 2010 Mar 19; 285(12): 8995-9007. (并列第一作者)(2010 影响因子5.3)

42:  Junfei Jin, Thomas D. Mullen, Qi Hou, Jacek Bielawski, Alicja Bielawska, Xiaoming Zhang, Lina M. Obeid, Yusuf A. Hannun, Yi-Te Hsu. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J. Lipid Res. 2009. 50: 2389–2397. (第一作者)(2009 年影响因子5.0)

43:  Qun Zhu, Xiaohong Shan, Heng Miao, Yibing Lu, Jiarong Xu, Na You, Chao Liu, Duan-fang Liao, Junfei Jin. Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet β-cells. FEBS Letters 583 (2009): 2136–2141. (通讯作者)(2009 年影响因子3.5)

44:  Wei Sun, Wei Hu, Ruijuan Xu, Junfei Jin, Zdzislaw M. Szulc, Guofeng Zhang, Sehamuddin H. Galadari, Lina M. Obeid, Cungui Mao. Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. FASEB J. 2009 Feb; 23(2):656-666. (第四作者)(2009 年影响因子6.4)

45:  Junfei Jin, Qi Hou, Thomas D. Mullen, Youssef H. Zeidan, Jacek Bielawski, Jacqueline M. Kraveka, Alicja Bielawska, Lina M. Obeid, Yusuf A. Hannun, Yi-Te Hsu. Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem. 2008 Sep 26;283(39):26509-26517. (第一作者)(2008 年影响因子5.5)

46:  Qun Zhu, Junfei Jin, Xiaohong Shan, Cuiping Liu, Xiaodong Mao, Kuanfeng Xu, Chao Liu. Chronic activation of neutral ceramidase protects beta-cells against cytokine-induced apoptosis. Acta Pharmacol Sin. 2008 May; 29(5):593-599. (并列第一作者)(2008 年影响因子1.7)

47:  Wei Sun, Ruijuan Xu, Wei Hu, Junfei jin, Heather Crellin, Jacek Bielawski, Zdzislaw Szulc, Bruce H. Thiers, Lina M. Obeid, Cungui Mao. Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. J Invest Dermatol. 2008 Feb;128 (2):389-397. (第四作者)(2008 年影响因子5.3)

48:  Junfei Jin, Paulette Krishack, Deliang Cao. Role of aldo-keto reductases in development of prostate and breast cancer. Front Biosci. 2006 Sep 1; 11: 2767-2773. (第一作者)(2006 年影响因子2.8)

49:  Ruijuan Xu, Junfei Jin, Wei Hu, Jacek Bielawski, Zdzislaw Szulc, Heather Crellin, Tarek A.Taha, Lina M. Obeid, Cungui Mao. Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J, 2006 Sep; 20(11):1813-1825. (并列第一作者)(2006 年影响因子6.7)