金俊飞
职  称: 研究员
职  务: 桂林医学院附属医院副院长
学  历: 博士研究生
所在科室: 肝胆胰外科实验室
出诊时间:

金俊飞,男,研究员,遗传学博士,留美博士后,中南大学湘雅医院博士生导师。曾任美国南卡罗莱纳医科大学Assistant ProfessorVisitingFaculty),在美国工作近10年后被桂林医学院以高层次人才引进。目前担任桂林医学院学术委员会副主任、桂林医学院附属医院副院长、桂林医学院广西肝脏损伤与修复分子医学重点实验室主任、桂林医学院中美健康与疾病脂质研究中心主任。教育部学位中心博士/硕士学位论文评审专家、中国生物物理学会代谢生物学学会第二届理事(广西唯一)、《中国动脉硬化杂志》第六届编辑委员会常务委员。

2019年,入选国家百千万人才工程,被授予有突出贡献中青年专家称号,同年入选广西壮族自治区第八批特聘专家2018年,入选广西壮族自治区优秀专家(第九批)、荣获广西发展战略优秀专家称号;2017年,入选广西高等学校高水平创新团队及卓越学者;2015年,获桂林市漓江学者(第二批);2014年,获桂林市拔尖人才(第四批);2013年,入选广西高校引进海外高层次人才百人计划学者(第一批)。

主要研究神经鞘脂代谢通路与细胞行为及相关疾病,取得了多项原创性成果。目前为止发表发表高水平论文37篇,其中Top期刊论文8篇;获广西科学技术奖自然科学类一等奖”1项(排名第12019年),获广西科学技术奖科学技术进步类一等奖”1项(排名第52016年),获首届广西创新争先奖1项(个人奖,2018年),获桂林市科学技术奖科学技术进步类一等奖1项(排名第22016年);主持国家自然科学基金3项(面上项目1项、地区基金2项),主持广西自然科学基金2项(重大项目1项、面上项目1项)。

 

部分代表性论文:

Xu Ye, Cunyan Li, Xuyu Zu, Minglin Lin, Qiang Liu, Jianghua Liu, Guoguo Xu, Zhiyong Chen, Yongliang Xu, Long Liu, Diteng Luo, Zhe Cao, Guiyuan Shi, Zirui Feng, Hongyu Deng, Qianjin Liao, Chuan Cai, Duan-Fang Liao, Jing Wang, Junfei Jin, Deliang Cao. A Large-Scale Multicenter Study Validates AKR1B10 as a New Prevalent Serum Marker for Detection of Hepatocellular Carcinoma. Hepatology. 2019 Jun; 69(6):2489-2501.  (共同通讯作者) (2019年影响因子14.971)

 Zhe Cao, Qianjin Liao, Min Su, Kai Huang, Junfei Jin, Deliang Cao. AKT and ERK dual inhibitors: The way forward? Cancer Letters. 2019 May 23;459:30-40. (共同通讯作者) (2019年影响因子6.508)

Zhe Cao, Ping Wu, Min Su, Hongyan Ling, Ramina Khoshaba, Chenfei Huang, Han Gao, Yan Zhao, Jinjun Chen, Qianjin Liao, Deliang Cao, Junfei Jin, Xuewen Zhang. Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway. J Cancer. 2019 May 12; 10(9):2025-2034.(共同通讯作者)(2019年影响因3.182

Yuekun Zhu, Chao Qu, Xuehui Hong, Yanyan Jia, Meihu Lin, Yunmei Luo, Fengqin Lin, Xiaolong Xie, Xiaoqi Xie, Juan Huang, Qin Wu, Xingfeng Qiu, Daxun Piao, Yanwei Xing, Tian Yu, Yuanfu Lu, Qiang Huang, Changyin Yu, Junfei Jin, Zhiyong Zhang. Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1. Cell Death Differ. 2019 Jan; 26(2):306-320.  (共同通讯作者)2019年影响因子8.086

Minglin Lin, Weijia Liao, Mingjun Dong, Rongping Zhu, Juan Xiao, Tian Sun, Zhiyong Chen, Bin Wu, Junfei Jin. Exosomal neutral sphingomyelinase 1 suppresses hepatocellular carcinoma via decreasing the ratio of sphingomyelin/ceramide. FEBS J. 2018 Oct; 285(20):3835-3848. (通讯作者)2018年影响因子4.530

Qin-You Tan, Qian Hu, Sheng-Nan Zhu, Lu-Lu Jia, Juan Xiao, Hua-Zhen Su, Shao-Yuan Huang, Jing Zhang, Junfei Jin. Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway. Drug Deliv. 2018 Nov; 25(1):1213-1223.(通讯作者) 2018年影响因子3.095

 Junfei Jin, Zhongyang Lu, Yanchun Li, Ji Hyun Ru, Maria F. Lopes-Virella, Yan Huang. LPS and Palmitate Synergistically Stimulate Sphingosine Kinase 1 and Increase Sphingosine 1 Phosphate in RAW264.7 Macrophages. J Leukoc Biol. 2018 Oct; 104(4):843-853. (第一作者) 2018年影响因子4.224

 Chenfei Huang, Zhe Cao, Jun Ma, Yi Shen, Yiwen Bu, Ramina Khoshaba, Guiyuan Shi, Dan Huang, Duan-Fang Liao, Haitao Ji, Junfei Jin, and Deliang Cao. AKR1B10 Activates Diacylglycerol (DAG) Second Messenger in Breast Cancer Cells. Mol Carcinog. 2018 Oct;57(10):1300-1310. (共同通讯作者) 2018年影响因子3.851

 Minglin Lin, Junfei Jin. Cancer, obesity, and diabetes: TKIs exert multiple effects on glucose homeostasis. Nat Rev Clin Oncol. 2017 May;14(5):268. (通讯作者) (2017年影响因子20.7)

Junfei Jin, Songqing He. The complement system is also important in immunogenic cell death. Nat Rev Immunol. 2017 Feb;17(2):143. (第一作者、通讯作者) (2017年影响因子39.9)

Qun Zhu, Jianjun Yang, Rongping Zhu, Xin Jiang, Wanlian Li, Songqing He, Junfei Jin. Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis. Apoptosis. 2016 Sep;21(9):1033-44. (通讯作者) (2016影响因子3.592)

Jessica Heinrichs, Jun Li, Hung Nguyen, Yongxia Wu, David Bastian, Anusara Daethanasanmak, M-Hanief Sofi, Steven Schutt, Chen Liu, Junfei Jin, Brian Betts, Claudio Anasetti, Xue-Zhong Yu. CD8 Tregs Promote GVHD Prevention and Overcome the Impaired GVL Effect Mediated by CD4 Tregs in Mice. Oncoimmunology. 2016 Mar 28;5(6):e1146842  (通讯作者) (2016年影响因子7.64)

Qun Zhu, Jian Kang, Heng Miao, Yamin Feng, Lijun Xiao, Zhigao Hu, Duan-Fang Liao, Yan Huang, Junfei Jin, Songqing He. Low-dose cytokine-induced neutral ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect. FEBS J. 2014 Jun;281(12):2861-2870.(通讯作者)(2014年影响因子4.0

Junfei Jin, Erika R. Machado, Hong Yu, Xiaoming Zhang, Zhongyang Lu, Yanchun Li, Maria F.Lopes-Virella, Keith L. Kirkwood, Yan Huang. Simvastatin Inhibits LPS-Induced Alveolar Bone Loss during Metabolic Syndrome. J Dent Res. 2014 Mar; 93(3):294-299, 2014. (第一作者)2014年影响因子4.1

Junfei Jin, Xiaoming Zhang, Zhongyang Lu, David M. Perry, Yanchun Li, Sarah Brice Russo, L.Ashley Cowart, Yusuf A. Hannun, Yan Huang. Acid Sphingomyelinase Plays a Key Role in Palmitic Acid-Amplified Inflammatory Signaling Triggered by Lipopolysaccharide at Low Concentration in Macrophages. Am J Physiol Endocrinol Metab. 2013 Oct; 305(7):E853-E867. (第一作者)2013年影响因子4.1

Qun Zhu, Lianku Lin, Qi Cheng, Qing Xu, Jingmei Zhang, Stephen Tomlinson, Junfei Jin, Xiaoping Chen, Songqing He. The role of acid sphingomyelinase and caspase 5 in hypoxia-induced HuR cleavage and subsequent apoptosis in hepatocytes. Biochim Biophys Acta. 2012 Dec; 1821(12):1453-1461.(通讯作者)(2012 年影响因子4.1

 Junfei Jin, Kamala P. Sundararaj, Devadoss J. Samuvel, Xiaoming Zhang, Yanchun Li, Zhongyang Lu, Maria F. Lopes-Virella, Yan Huang. Different signaling mechanisms regulating IL-6 expression by LPS between gingival fibroblasts and mononuclear cells: seeking the common target. Clin Immunol. 2012 May; 143(2):188-199. (第一作者)2012 年影响因子3.8

Sudha Talwar, Junfei Jin, Brittany Carroll, Angen Liu, Marion Boyd Gillespie, Viswanathan Palanisamy. Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc expression after hypoxic stress. J Biol Chem. 2011 Sep 16; 286(37):32333-32343. (并列第一作者)2011 年影响因子4.8

Qi Hou, Junfei Jin, Hui Zhou, Sergei A. Novgorodov, Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Yi-Te Hsu. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res. 2011 Feb; 52(2):278-288. (并列第一作者)2011 年影响因子5.6

Wei Sun, Junfei Jin, Ruijuan Xu, Wei Hu, Zdzislaw M. Szulc, Jacek Bielawski, Lina M. Obeid, Cungui Mao. Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2). J Biol Chem. 2010 Mar 19; 285(12): 8995-9007. (并列第一作者)2010年 影响因子5.3

Junfei Jin, Thomas D. Mullen, Qi Hou, Jacek Bielawski, Alicja Bielawska, Xiaoming Zhang, Lina M. Obeid, Yusuf A. Hannun, Yi-Te Hsu. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec; 50(12): 2389–2397. (第一作者)2009 年影响因子5.0

 Qun Zhu, Xiaohong Shan, Heng Miao, Yibing Lu, Jiarong Xu, Na You, Chao Liu, Duan-fang Liao, Junfei Jin. Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet β-cells. FEBS Lett. 2009 Jun 18; 583(12): 2136–2141. (通讯作者)(2009 年影响因子3.5

Junfei Jin, Qi Hou, Thomas D. Mullen, Youssef H. Zeidan, Jacek Bielawski, Jacqueline M. Kraveka, Alicja Bielawska, Lina M. Obeid, Yusuf A. Hannun, Yi-Te Hsu. Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem. 2008 Sep 26; 283(39):26509-26517. (第一作者)2008 年影响因子5.5

Ruijuan Xu, Junfei Jin, Wei Hu, Jacek Bielawski, Zdzislaw Szulc, Heather Crellin, Tarek A.Taha, Lina M. Obeid, Cungui Mao. Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J, 2006 Sep; 20(11):1813-1825. (并列第一作者)2006 年影响因子6.7